Which class of drugs is used for symptomatic relief in Myasthenia Gravis?

Which class of drugs is used for symptomatic relief in Myasthenia Gravis?

• A. Beta-blockers
• B. Anticholinesterase drugs
• C. Calcium channel blockers
• D. Opioids

Answer: (B)

Anticholinesterase drugs are specifically designed to enhance neurotransmission at the neuromuscular junction by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. In Myasthenia Gravis, a condition characterized by weakness and rapid fatigue of voluntary muscles, there is a reduction in the number of functional acetylcholine receptors due to autoantibodies. By prolonging the action of acetylcholine, anticholinesterase drugs increase the availability of acetylcholine to bind to the remaining receptors, thereby improving muscle strength and providing symptomatic relief. Other classes of drugs mentioned are not indicated for the treatment of Myasthenia Gravis. Beta-blockers can aggravate muscle weakness by blocking the sympathetic stimulation and potentially interfering with muscle contraction. Calcium channel blockers do not play a role in managing the symptoms of this autoimmune disease, as they primarily target cardiac and smooth muscle function. Opioids are used for pain relief but would not address the underlying issue of neuromuscular transmission in Myasthenia Gravis.

Anticholinesterase drugs are specifically designed to enhance neurotransmission at the neuromuscular junction by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine. In Myasthenia Gravis, a condition characterized by weakness and rapid fatigue of voluntary muscles, there is a reduction in the number of functional acetylcholine receptors due to autoantibodies. By prolonging the action of acetylcholine, anticholinesterase drugs increase the availability of acetylcholine to bind to the remaining receptors, thereby improving muscle strength and providing symptomatic relief.

Other classes of drugs mentioned are not indicated for the treatment of Myasthenia Gravis. Beta-blockers can aggravate muscle weakness by blocking the sympathetic stimulation and potentially interfering with muscle contraction. Calcium channel blockers do not play a role in managing the symptoms of this autoimmune disease, as they primarily target cardiac and smooth muscle function. Opioids are used for pain relief but would not address the underlying issue of neuromuscular transmission in Myasthenia Gravis.